What Foods To Avoid When Taking Furosemide?

How does furosemide work? Furosemide is a type of medicine called a loop diuretic. A diuretic makes your body get rid of extra fluid through your kidneys. A loop diuretic works on a specific part of the kidney called the loop of Henle to increase the salt and water you pee out.

This means you have less fluid in your tissues which helps get rid of swelling (oedema).
You will also have less fluid in your blood, which helps reduce blood pressure.
How long does furosemide take to work? Furosemide starts to work within 1 hour but it may take a few weeks to fully take effect.
If you’re taking furosemide for high blood pressure, you may not have any symptoms.

In this case, you may not feel any different when you take furosemide. This does not mean that the medicine is not working. It’s important to keep taking it. How long does it work for? A dose of furosemide works for about 6 hours. Are there any long-term side effects? Furosemide is safe to take for a long time, but you will have to see your doctor or nurse regularly for blood and urine tests.

These make sure the chemicals in your blood are properly balanced.
How often you need to see your doctor or nurse for these tests will depend on the reason you’re taking furosemide, if your dose has changed recently, or if you have any other health problems.
How does furosemide compare with other diuretic medicines? There are other diuretics that work in a similar way to furosemide.

There are 3 different types of diuretic, and each type of diuretic works on a different part of the kidney:

loop diuretics (such as furosemide) including bumetanide and torasemide can also be used to treat heart failure. Torasemide can also be used to treat high blood pressurethiazide diuretics such as bendroflumethiazide and indapamide, are used in low doses to treat high blood pressure, and in higher doses to treat heart failurepotassium-sparing diuretics such as spironolactone and eplerenone, can be used to treat heart failure. These can also be used if you lose too much potassium with other diuretics

Can I stop taking furosemide now my blood pressure is lower? Even if furosemide brings down your blood pressure successfully, it’s best to carry on taking it. If you stop taking it, your blood pressure could go back up again. If you need medicines to lower your blood pressure, you’ll probably need them for the rest of your life.

Remember, by keeping your blood pressure low, you’re protecting yourself against having a heart attack or stroke in the future.
How much fluid should I drink while I’m taking furosemide? It’s usually best to drink normally while you’re taking furosemide.
A good rule is to drink enough fluid so that you’re not thirsty for long periods, and to steadily increase your fluid intake when exercising and during hot weather.

Passing pale, clear pee is a good sign that you’re drinking enough. However, if you have heart failure or kidney problems you might need to limit how much fluid you drink. Your doctor or nurse will tell you exactly how much you need to drink each day. Can I take furosemide to lose weight? If you’re taking furosemide for high blood pressure or oedema you may lose a bit of weight as your body loses water.

But do not take furosemide specifically to lose weight.
Only take furosemide if it’s been prescribed, and only for the reason your doctor has prescribed it for you.
Can I take furosemide before surgery? Tell your doctor that you’re taking furosemide if you’re going to be put to sleep with a general anaesthetic for an operation or you’re going to have a major operation, such as a Caesarean section, without a general anaesthetic.

Furosemide can reduce your blood pressure when it’s used with a general anaesthetic. Your doctor may advise you to stop taking furosemide 24 hours before surgery. Will it affect my contraception? Furosemide will not affect any type of contraception. However, some types of hormonal contraception, like the combined pill and contraceptive patch, are not usually recommended if you’re taking furosemide.

This is because some hormonal contraceptives can raise your blood pressure and stop the medicine working properly. Talk to your doctor if you’re taking or using hormonal contraceptives. If furosemide makes you sick (vomit), your contraceptive pills may not protect you from pregnancy. Check the pill packet to find out what to do.

Read more about what to do if you’re on the pill and you have diarrhoea, Can I drive or ride a bike? Furosemide can make you feel confused and dizzy. If this happens to you, do not drive, cycle, or use machinery or tools until you feel back to normal.

It’s an offence to drive a car if your ability to drive safely is affected. It’s your responsibility to decide if it’s safe to drive. If you’re in any doubt, do not drive. Talk to your doctor or pharmacist if you’re unsure whether it’s safe for you to drive while taking furosemide. GOV.UK has more information on the law on drugs and driving,

Can I drink alcohol with while taking furosemide? During the first few days of taking furosemide, it’s best to stop drinking alcohol until you see how the medicine affects you. It may lower your blood pressure and make you feel dizzy. Is there any food or drink I need to avoid? If you’re taking a diuretic such as furosemide, it’s important not to have too much salt in your food because this can stop it working.

Do not eat foods that have a lot of salt in them, such as processed foods or ready-meals.
Do not add extra salt when you’re cooking or at the table.
Also, do not buy salt substitutes, like Lo-Salt, instead of ordinary table salt, as they contain a lot of potassium, which can affect the way certain medicines work, or cause side effects.

Adults are advised to eat no more than 6 grams of salt a day. Your doctor will tell you if you need to eat even less than this. Can lifestyle changes help high blood pressure? You can boost your general health, plus the health of your heart, by making some key lifestyle changes.

Quit smoking – smoking increases your heart rate and blood pressure. Quitting smoking brings down your blood pressure and relieves heart failure symptoms. Try to avoid secondhand smoke too. Cut down on alcohol – drinking too much alcohol raises blood pressure over time and also makes heart failure worse. Men and women should not drink more than 14 units of alcohol a week.Be more active – regular exercise lowers blood pressure by keeping your heart and blood vessels in good condition. It does not need to be too energetic, walking every day can help. Eat healthily – aim to eat a diet that includes plenty of fruit and vegetables, wholegrains, fat-free or low-fat dairy products and lean proteins. It’s a good idea to follow these tips for a lower salt diet, however, it’s important not to go on a low-salt diet while taking this medicine, as that could make your sodium levels too low. People need salt in their diet but eating too much salt is the biggest cause of high blood pressure. The more salt you eat, the higher your blood pressure will be. Aim for no more than 6g of salt a day.Manage stress – when you’re anxious or upset, your heart beats faster, you breathe more heavily and your blood pressure often goes up. This can make heart failure worse too. Find ways to reduce stress in your life. To give your heart a rest, try napping or putting your feet up when possible. Spend time with friends and family to be social and help avoid stress. Vaccinations – if you have heart failure, it’s recommended that you have the flu vaccine every year and the pneumococcal vaccine as recommended by your GP. Ask your doctor about these vaccinations. You can have them free on the NHS if you have heart failure. The coronavirus (COVID-19) vaccine is recommended for most people. Make sure you’ve had all the doses that you are eligible for. Talk to your doctor if you think you might be in one of the at risk groups.

Contents

1 Should you drink milk with furosemide?
- - 1.0.1 Can you drink coffee while taking furosemide?
- 1.1 Should I drink more water when taking furosemide?
2 What not to do when taking furosemide?
- - 2.0.1 Can I have a glass of wine while taking furosemide?
  - 2.0.2 How long does it take for for furosemide to reduce swelling?
3 How often do you pee on furosemide?
4 Can you eat bananas on diuretics?
- - 4.0.1 Is banana good for diuretics?
5 Does furosemide make you sleepy?
- 5.1 What is the most common side effect of furosemide?
- 5.2 How do you know if furosemide is working?
  - 5.2.1 What happens if you don t drink enough water while taking a diuretic?
  - 5.2.2 What is the best time of day to take furosemide?
6 Do you eat potassium with furosemide?
- 6.1 When should you avoid furosemide?
7 How long can you take furosemide for?
8 Is 20 mg of furosemide a lot?
9 What organ does furosemide affect?
- - 9.0.1 Does milk have a diuretic effect?
10 What should you avoid when taking diuretics?
11 Is milk a good diuretic?
12 Why do you take furosemide on an empty stomach?

Should you drink milk with furosemide?

Are there any precautions about food or other medicines? – Furosemide and bumetanide can be given with or without food or milk. These medicines can decrease the potassium level in the blood, so your child may need to have potassium blood tests. There are two ways to replace potassium: by taking a supplement, or by making changes in the diet. Foods high in potassium include:

bananas oranges tomatoes peppers infant formula whole milk fresh meat, poultry, and fish

If your child is not taking a potassium supplement, be sure some of these foods are eaten every day. For information on other foods that contain potassium, ask the doctor, nurse or nutritionist.

Can you drink coffee while taking furosemide?

Taking caffeine with water pills might cause potassium levels to drop too low. Some ‘water pills’ that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril, Microzide), and others.

Should I drink more water when taking furosemide?

Things you must do – Tell all the doctors, dentists and pharmacists who are treating you that you are taking Lasix. If you are about to be started on any new medicine, tell your doctor and pharmacist that you are taking Lasix. If you plan to have a surgery that needs a general anaesthetic, tell your doctor or dentist that you are taking this medicine.

Your blood pressure may drop suddenly. If you become pregnant while you are taking this medicine, tell your doctor or pharmacist immediately. Tell your doctor if you have excessive vomiting or diarrhoea while taking Lasix or if you experience any of the following symptoms: dry mouth or thirst fainting weakness, tiredness or drowsiness muscle pain or cramps fast heart beat passing less urine than normal If you experience these symptoms, you may be dehydrated because you are losing too much water.

Make sure you drink enough water during any exercise and during hot weather when you are taking Lasix, especially if you sweat a lot. If you do not drink enough water while taking Lasix, you may feel faint or light-headed or sick. This is because your blood pressure is dropping suddenly and you are dehydrating.

What not to do when taking furosemide?

This means you have less fluid in your tissues which helps get rid of swelling (oedema). You will also have less fluid in your blood, which helps reduce blood pressure. How long does furosemide take to work? Furosemide starts to work within 1 hour but it may take a few weeks to fully take effect. If you’re taking furosemide for high blood pressure, you may not have any symptoms.

These make sure the chemicals in your blood are properly balanced.
How often you need to see your doctor or nurse for these tests will depend on the reason you’re taking furosemide, if your dose has changed recently, or if you have any other health problems.
How does furosemide compare with other diuretic medicines? There are other diuretics that work in a similar way to furosemide.

There are 3 different types of diuretic, and each type of diuretic works on a different part of the kidney:

Remember, by keeping your blood pressure low, you’re protecting yourself against having a heart attack or stroke in the future.
How much fluid should I drink while I’m taking furosemide? It’s usually best to drink normally while you’re taking furosemide.
A good rule is to drink enough fluid so that you’re not thirsty for long periods, and to steadily increase your fluid intake when exercising and during hot weather.

But do not take furosemide specifically to lose weight.
Only take furosemide if it’s been prescribed, and only for the reason your doctor has prescribed it for you.
Can I take furosemide before surgery? Tell your doctor that you’re taking furosemide if you’re going to be put to sleep with a general anaesthetic for an operation or you’re going to have a major operation, such as a Caesarean section, without a general anaesthetic.

This is because some hormonal contraceptives can raise your blood pressure and stop the medicine working properly.
Talk to your doctor if you’re taking or using hormonal contraceptives.
If furosemide makes you sick (vomit), your contraceptive pills may not protect you from pregnancy.
Check the pill packet to find out what to do.

It’s an offence to drive a car if your ability to drive safely is affected.
It’s your responsibility to decide if it’s safe to drive.
If you’re in any doubt, do not drive.
Talk to your doctor or pharmacist if you’re unsure whether it’s safe for you to drive while taking furosemide.
GOV.UK has more information on the law on drugs and driving,

Do not eat foods that have a lot of salt in them, such as processed foods or ready-meals. Do not add extra salt when you’re cooking or at the table. Also, do not buy salt substitutes, like Lo-Salt, instead of ordinary table salt, as they contain a lot of potassium, which can affect the way certain medicines work, or cause side effects.

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Can I have a glass of wine while taking furosemide?

If you’re taking blood pressure medications, it’s usually best to avoid or minimize alcohol. That’s because it may prevent your medications from working as well, or cause worse side effects. The same holds true for combining alcohol with furosemide.

How long does it take for for furosemide to reduce swelling?

Key facts –

You will usually take furosemide once a day in the morning. Some people take it twice a day, once in the morning and again at lunchtime.Furosemide starts to work within 1 hour. Most people need to pee about 30 minutes after taking furosemide, and again within a few hours.It can take furosemide a few weeks to take full effect and start helping with your high blood pressure or oedema.Furosemide does not usually upset your stomach. You can take it with or without food.The main side effect of furosemide is peeing more often than normal. Do not take furosemide after 4pm or you may have to wake in the night to go to the toilet.

Page last reviewed: 21 February 2022 Next review due: 21 February 2025

How often do you pee on furosemide?

You’ll likely start urinating more frequently within one hour of taking furosemide. This effect can last up to 8 hours. Plan on having access to the restroom, especially when you first start taking it. If you’re waking up in the middle of the night to hit the restroom, taking your dose earlier in the day can help.

Can you eat bananas on diuretics?

Commonly known as ” water pills,” these drugs help your kidneys get rid of extra water and salt from your body through your urine. Because you have less total fluid in your blood vessels, like a garden hose that’s not turned on all the way, the pressure inside will be lower.

Aldactone ( spironolactone ) Bumex ( bumetanide ) Demadex ( torsemide ) Esidrix ( hydrochlorothiazide )Lasix ( furosemide ) Zaroxolyn ( metolazone )

Diuretics come in different categories:

Thiazide-like. These get rid of a moderate amount of water, They can be used for a long time.Loop. They’re more powerful and are very useful in emergencies. Potassium -sparing. They help you keep potassium as you’re getting rid of water and salt.

Different diuretics can be taken together, and you can take them with other medications, sometimes in the same pill. Your doctor may recommend a diuretic if you have:

Edema, Diuretics lessen swelling that usually happens in the legs. High blood pressure, Thiazide diuretics lower blood pressure. That lowers your chance of a stroke or heart attack, Heart failure, Diuretics ease swelling and congestion in the lungs, You’ll usually get a loop diuretic for heart failure. Kidney problems. You’ll keep less water, Liver problems. If you have cirrhosis, a diuretic will ease the fluid buildup you’ll get with it. Glaucoma, They’ll reduce the pressure in your eye,

Before you’re prescribed a diuretic, tell your doctor if you have diabetes, kidney disease, liver disease, or gout, Follow the directions on the label. If you’re taking one dose a day, take it in the morning with your breakfast or right after. If you’re taking more than one dose a day, take the last one no later than 4 p.m.

The number of doses you take each day, the time allowed between doses, and how long you need to take a diuretic will depend on the type prescribed, as well as your condition. Weigh yourself at the same time every day (on the same scale) and write down your weight, Call your doctor if you gain 3 pounds in one day or 5 pounds in one week.

While you’re taking these, have your blood pressure and kidney strength tested regularly. Diuretics can change your blood potassium and magnesium levels. Keep all your doctor and lab appointments so your response to this medicine can be tracked. To avoid a potential problem, tell your doctor and pharmacist about all the medicines you are taking, including:

Herbal preparationsOver-the-counter drugs VitaminsNutrition supplements

Diuretics are often prescribed with other drugs. If you have more side effects when you take them together, contact your doctor. You may need to change the times you take each one. Before a diuretic is prescribed, tell your doctor if you’re taking:

Medication for high blood pressure DigoxinIndomethacin Probenecid Corticosteroids

Some diuretics may require you to avoid or eat certain foods. Follow your doctor’s advice, which may include:

A low-salt diet A potassium supplement or high-potassium foods such as bananas and orange juice.

As always, talk with your doctor. Let your doctor know what medications (prescription and over-the-counter), supplements, and herbal remedies you use. Also, tell them about other medical problems you have. They may want to regularly check your blood pressure as well as test your blood and urine for levels of specific minerals and to see how well your kidneys are working.

They’ll probably tell you to follow a low-sodium diet and limit how much salt you eat. Because some diuretics also pull potassium out of your body, you might need to eat more foods like bananas, sweet potatoes, spinach, and lentils, or take a potassium supplement. On the other hand, if you’re taking a potassium-sparing diuretic, such as amiloride (Midamar), spironolactone (Aldactone), or triamterene (Dyrenium), they may want you to avoid potassium-rich foods, salt substitutes, low-sodium milk, and other sources of potassium.

If you only need one dose a day, you might want to take your diuretic in the morning so you can sleep through the night instead of getting up to go to the bathroom. Avoid alcohol and medicines to help you sleep, They may make side effects worse. The water that comes out of your body has to go somewhere, so you can expect to be peeing more and more, often for several hours after a dose.

If you’re taking two doses each day, take the second dose no later than late afternoon so you can sleep through the night without waking up to urinate. You also run the risk of getting dehydrated, and simply drinking more fluids may not be enough. Call your doctor if you’re very thirsty or have a very dry mouth, your pee is a deep yellow, you aren’t peeing much or get constipated, or you have a bad headache,

You may have extreme tiredness or weakness. These should ease as your body gets used to the medicine. Call your doctor if these symptoms hang around. That could mean your dose needs to be adjusted. You may feel dizzy or lightheaded, especially when you stand up, if your blood pressure has dropped too low, or you’re getting dehydrated.

Your blood chemistry can get thrown off.
You could have too little or too much sodium or potassium in your system.
This can make you tired or weak or give you muscle cramps or a headache,
It’s rare, but your heart may speed up (over 100 beats a minute) or you might start throwing up because of a dangerously low potassium level.

Diuretics may make it harder for you to control your blood sugar, which can lead to diabetes if you don’t already have it. You might be more likely to get gout, Taking combination pills or multiple medicines could boost these side effects. To help lower those odds, ask your doctor when during the day you should take each medication.

Fever, sore throat, cough, ringing in the ears, unusual bleeding or bruising, rapid and excessive weight loss Skin rash Loss of appetite, nausea, vomiting, or muscle cramps

Also call them if you have any other symptoms that concern you. Some diuretics are sulfa drugs, so they could cause a reaction if you’re allergic. Older people tend to have more side effects such as fainting and dizziness from dehydration, You’ll need to work closely with your doctor.

Is banana good for diuretics?

Banana – Bananas are a go-to for busting bloat. One medium banana has more than 400 mg of potassium, which is a natural diuretic. If you’ve been avoiding bananas because you worry they might constipate you, just stick to ripe bananas. Green, unripened bananas can constipate you, but the ripe ones are full of fiber, which will help get things moving through your digestive tract.

Does furosemide make you sleepy?

Side Effects – Dizziness, lightheadedness, headache, or blurred vision may occur as your body adjusts to the medication, If any of these effects last or get worse, tell your doctor or pharmacist promptly. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects.
Many people using this medication do not have serious side effects.
This medication may cause dehydration and electrolyte imbalance.
Tell your doctor right away if you have any of these unlikely but serious side effects: muscle cramps, weakness, unusual tiredness, confusion, severe dizziness, fainting, drowsiness, unusual dry mouth /thirst, nausea, vomiting, fast/irregular heartbeat.

Tell your doctor right away if any of these unlikely but serious side effects occur: signs of kidney problems (such as change in the amount of urine), numbness/tingling/pain/redness/swelling of the arms/legs, hearing changes (such as ringing in the ears, temporary or permanent decreased hearing/ deafness ), stomach / abdominal pain, yellowing eyes / skin,

A very serious allergic reaction to this drug is rare.
However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching /swelling (especially of the face/ tongue /throat), severe dizziness, trouble breathing,
This is not a complete list of possible side effects.

If you notice other effects not listed above, contact your doctor or pharmacist. In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada – Call your doctor for medical advice about side effects.

What is the most common side effect of furosemide?

Before taking furosemide, –

tell your doctor and pharmacist if you are allergic to furosemide, sulfonamide medications, any other medications, or any of the ingredients in furosemide tablets or solution. Ask your pharmacist or check the patient information for a list of the ingredients.tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aminoglycoside antibiotics such as amikacin, gentamicin (Garamycin), or tobramycin (Bethkis, Tobi); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril (Capoten), fosinopril, lisinopril (in Prinzide, in Zestoretic), moexipril (Univasc, in Uniretic), perindopril (Aceon), quinapril (Accupril, in Accuretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); angiotensin II receptor antagonists (ARB) such as azilsartan (Edarbi, Edarbyclor), candesartan (Atacand, in Atacand HCT), eprosartan (Teveten, in Teveten HCT), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, Benicar HCT), telmisartan (Micardis, in Micardis HCT), and valsartan (Diovan, in Diovan HCT, Exforge); aspirin and other salicylates; barbiturates such as phenobarbital and secobarbital (Seconal); corticosteroids such as betamethasone (Celestone), budesonide (Entocort), cortisone (Cortone), dexamethasone (Decadron, Dexpak, Dexasone, others), fludrocortisone (Floriner), hydrocortisone (Cortef, Hydrocortone), methylprednisolone (Medrol, Meprolone, others), prednisolone (Prelone, others), prednisone (Deltasone, Meticorten, Sterapred, others), and triamcinolone (Aristocort, Azmacort); cisplatin (Platinol); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin), ethacrynic acid (Edecrin); indomethacin (Indocin); laxatives; lithium (Lithobid); medications for diabetes, high blood pressure and pain; methotrexate (Trexall); probenecid (Probalan, Probenemid); and phenytoin (Dilantin, Phenytek). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.if you are taking sucralfate (Carafate), take it 2 hours before or after you take furosemide.tell your doctor if you have kidney disease. Your doctor may tell you not to take furosemide.tell your doctor if you have or have ever had any condition that stops your bladder from emptying completely, diabetes, gout, systemic lupus erythematosus (SLE, a chronic inflammatory condition), or liver disease.tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. Do not breast-feed while taking this medicine. If you become pregnant while taking furosemide, call your doctor.if you are having surgery, tell the doctor that you are using furosemide.plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Furosemide may make your skin sensitive to sunlight.you should know that furosemide may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking furosemide. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. Alcohol can add to these side effects.

If your doctor prescribes a low-salt or low-sodium diet, or to eat or drink increased amounts of potassium-rich foods (e.g., bananas, prunes, raisins, and orange juice) in your diet, follow these instructions carefully. Take the missed dose as soon as you remember it.

How do you know if furosemide is working?

How can I tell if furosemide isn’t working? – Furosemide works by removing excess fluid from your body. This helps lower your blood pressure and reduce swelling from fluid buildup. When you start taking the drug, you may notice you’re urinating more often than usual.

If you’re taking the drug for swelling, you may notice that your swelling has gone down with furosemide. If you’re taking furosemide for high blood pressure, your doctor may ask you to check your blood pressure more often during treatment. If the drug is working, you should notice your blood pressure readings are improved with furosemide.

Your doctor will monitor you while you take furosemide. Keep in mind that it may take some time for the drug to improve your condition. If your doctor thinks that furosemide isn’t working for you, they may adjust your dose of the drug. If the drug still isn’t working, they may discuss other treatment options with you.

What happens if you don t drink enough water while taking a diuretic?

Can diuretics cause dehydration? – Yes, if you’re taking too high a dose of a diuretic or not drinking enough fluids, you can get dehydrated.

What is the best time of day to take furosemide?

Furosemide – Lasix, Frusol. Hypertension medicine side effects

Furosemide is a ‘water tablet’ (a diuretic).It is best taken in the morning.Any side-effects are usually mild, but can include feeling sick (nausea) or dizzy.

table>

Type of medicine A loop diuretic Used for Water retention (oedema); high blood pressure (hypertension) Also called Frusol ® ; Combination brand: Frumil® (furosemide with – this combination is also called co-amilofruse) Available as Tablets and oral liquid medicine

Furosemide belongs to a group of medicines called, A diuretic is a medicine which increases the amount of urine that you pass out from your kidneys. They are often referred to as ‘water tablets’. Furosemide is used to clear excess fluid from your body in conditions where your body retains more than it needs.

This extra fluid causes you to feel breathless and tired, and your feet and ankles to swell – it is called water retention (oedema), and it is commonly caused by,
Diuretics are also a common treatment for,
Furosemide is prescribed for high blood pressure when it cannot be sufficiently controlled by other diuretics.

Furosemide can be used on its own as a diuretic, or it can be prescribed as a combination tablet alongside other diuretics such as triamterene, amiloride or spironolactone. Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken.

If you are pregnant or breastfeeding.If you have any difficulties passing urine, or if you have prostate problems.If you have gout or diabetes (diabetes mellitus). These conditions can be made worse by diuretics.If you have been told you have very low sodium or potassium levels in your blood.If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.If you have ever had an allergic reaction to a medicine.

Before you start the treatment, read the manufacturer’s printed information leaflet from inside the pack. It will give you more information about furosemide and it will also provide you with a full list of the side-effects which you could experience from taking it.Take furosemide exactly as your doctor tells you to. It is usual to be prescribed one dose to take each day, and you will be asked to take it preferably in the morning. Some people could be asked to take two doses a day, in which case one dose should be taken in the morning and the other early-mid afternoon. Your doctor will tell you how many tablets (or how much liquid medicine) to take for each dose. You will find the directions for taking the doses printed on the label of the pack, to remind you about what the doctor said to you.Although furosemide is preferably taken in the morning, you can take it at a time to suit your schedule. For example, if you want to go out in the morning and don’t want to have to find a toilet, you can delay taking your dose until later. However, it is best if you take it no later than mid-afternoon. This is because you will find you need to go to the toilet a couple of times within a few hours of taking it and this will disturb your sleep if you take it too late in the day.Swallow the tablet with a drink of water. You can take furosemide either with or without food.If you forget to take a dose, take it as soon as you remember. However, if it is after 4 pm in the afternoon, you should leave out the forgotten dose and continue as usual the next day. Do not take two doses together to make up for a missed dose.

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Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. The balance of salts in your blood may be upset by furosemide. Your doctor may want you to have a blood test from time to time to check for this.Diuretics like furosemide help you to lose water. Occasionally you may lose too much and become lacking in fluid in the body (dehydrated). Let your doctor know if you feel constantly thirsty and tired, your mouth is dry, you have muscle cramps, or your skin looks and feels dry.If you have been prescribed furosemide for high blood pressure, your treatment is likely to be long-term. Although many people with high blood pressure do not feel unwell, if left untreated, high blood pressure can harm your heart and damage your blood vessels. This damage may later result in a heart attack, stroke, or kidney problems, so it is important that you continue to take furosemide regularly to help reduce the risk of this. You may also be given some lifestyle or dietary advice by your doctor, such as stopping smoking, reducing the amount of salt in your diet and taking some regular exercise. Following this advice will also help to reduce the risk of damage to your heart and blood vessels.Drinking alcohol while you are on furosemide could make you feel dizzy. Ask for your doctor’s advice about whether you should avoid alcohol.If you buy any medicines ‘over the counter’, check with a pharmacist that they are safe to take with your prescribed medicines.If you have diabetes, furosemide could affect your blood sugar levels. Test your blood sugar regularly and speak with your doctor if you notice any significant changes.If you are due to have an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the more common ones associated with furosemide. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer’s printed information leaflet supplied with the medicine.

Furosemide side-effects	What can I do if I experience this?
Feeling sick (nausea), stomach upset	This is usually mild, but it may help to take furosemide after food
Feeling dizzy, particularly when you stand up (due to low blood pressure)	Getting up and moving more slowly should help. Do not drive and do not use tools or machines while affected
Dry mouth	Try chewing sugar-free gum or sucking sugar-free sweets
Blurred vision, headache, feeling tired	If any of these become troublesome, speak with your doctor
Changes to the levels of minerals in your body	Your doctor will ask you to have blood tests to check for this

If you experience any other symptoms which you think may be due to the medicine, speak with your doctor or pharmacist for further advice.

Keep all medicines out of the reach and sight of children.Store in a cool, dry place, away from direct heat and light.

Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty. This medicine is for you. Never give it to other people even if their condition appears to be the same as yours. Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you. If you have any questions about this medicine, ask your pharmacist.

Furosemide – Lasix, Frusol. Hypertension medicine side effects

Do you eat potassium with furosemide?

Tips for taking diuretic medications – Harvard Health Diuretics, commonly called “water pills,” are the oldest and some of the least expensive class of drugs used to treat, They help the kidneys eliminate sodium and water from the body. This process decreases blood volume, so the heart has less to pump with each beat, which in turn lowers blood pressure.

People with, who often gain weight because their bodies hold onto excess fluid (a condition called edema), are often prescribed diuretic medications. Not surprisingly, one of the most common side effects of taking water pills is frequent urination. Other possible side effects include lightheadedness, fatigue, bowel changes, and muscle cramps.

Men may occasionally experience, In addition to getting rid of extra salt in your body, diuretic medications also affect levels of, This mineral plays a key role in controlling blood pressure, as well as nerve and muscle function. In general, your kidneys help regulate potassium levels in your blood.

But age,, heart failure, and certain other conditions may impair kidney function.
And while some water pills tend to lower potassium levels, others have the opposite effect.
Thiazide diuretics, such as chlorothiazide (Diuril), chlorthalidone (Hygroton), and hydrochlorothiazide (Esidrix, HydroDiuril, Microzide) tend to deplete potassium levels.

So do loop diuretics, such as bumetanide (Bumex) and furosemide (Lasix). If you take these medications, your doctor will likely encourage you to eat more potassium rich foods and beverages and limit salt intake. Potassium-sparing diuretics, which include amiloride (Midamor), spironolactone (Aldactone), and eplerenone (Inspra), avoid the potential problem of potassium loss.

But the opposite problem can occur. If potassium levels become too high, it can cause dangerous heart rhythm problems and even cardiac arrest. People with high blood pressure or heart failure are often advised to limit how much salt or sodium they consume. One way to do that is to use salt substitutes, but these products are high in potassium—a quarter teaspoon of one brand contains about 800 mg of potassium.

So, people who take potassium-sparing diuretics should avoid these products.

If you take any diuretic medication, ask your doctor whether you need periodic testing of your potassium and kidney function. To learn more about managing hypertension, buy ” ” – Executive Editor, Harvard Heart Letter

As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. : Tips for taking diuretic medications – Harvard Health

When should you avoid furosemide?

Who may not be able to take furosemide – Furosemide is not suitable for everyone. To make sure it’s safe for you, tell your doctor if you have:

ever had an allergic reaction to furosemide or any other medicine low blood pressure (hypotension) signs of dehydration, such as being thirsty, having a dry mouth and dark peeliver disease diabetes any difficulty peeing Addison’s disease, a rare disorder of the adrenal glands gout

Tell your doctor that you are taking furosemide if you’re going to have:

a glucose testa test (such as an X-ray or scan) that involves using a dye containing iodine being injected into your blooda major operation or a general anaesthetic to put you to sleep

Page last reviewed: 21 February 2022 Next review due: 21 February 2025

How long can you take furosemide for?

Depending on why you’re on furosemide, you may have to take it for a long time, even for the rest of your life.

Is 20 mg of furosemide a lot?

Adults: The typical starting dose ranges from 20 mg to 80 mg by mouth once. Your provider will adjust your dose depending on how your body responds to this medication. Once your provider finds a dose that works, you typically take furosemide (Lasix) once or twice daily. The maximum recommended dose is 80 mg daily.

What organ does furosemide affect?

Summary Furosemide is a loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension. Brand Names Furoscix, Lasix Generic Name Furosemide DrugBank Accession Number DB00695 Background Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body.

It is an anthranilic acid derivative.9 Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure.10 It mainly works by inhibiting electrolyte reabsorption from the kidneys and enhancing the excretion of water from the body.

Furosemide has a fast onset and short duration of action and has been used safely and effectively in both pediatric and adult patients.1 The use of furosemide is particularly beneficial in clinical settings that require a drug with a higher diuretic potential. Weight Average: 330.744 Monoisotopic: 330.007719869 Chemical Formula C 12 H 11 ClN 2 O 5 S Synonyms

2-Furfurylamino-4-chloro-5-sulfamoylbenzoic acid
4-Chloro-5-sulfamoyl-N-furfuryl-anthranilic acid
4-Chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid
4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid
Frusemide
Furosemid
Furosemida
Furosemide
Furosemidu
Furosemidum

External IDs

LB-502
NSC-269420

Indication Furosemide is indicated for the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome, in adults and pediatric patients.9 Oral furosemide is indicated alone for the management of mild to moderate hypertension or severe hypertension in combination with other antihypertensive medications.12 Intravenous furosemide is indicated as adjunctive therapy in acute pulmonary edema when a rapid onset of diuresis is desired.9 Subcutaneous furosemide is indicated for the treatment of congestion due to fluid overload in adults with NYHA Class II/III chronic heart failure. Reduce drug development failure rates Build, train, & validate machine-learning models with evidence-based and structured datasets. Build, train, & validate predictive machine-learning models with structured datasets. Associated Conditions

Acute Pulmonary Edema
Ascites
Body Fluid Retention
Edema
Hypertension
Mild to Moderate Hypertension
Chest congestion

Contraindications & Blackbox Warnings Avoid life-threatening adverse drug events Improve clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more. Avoid life-threatening adverse drug events & improve clinical decision support.

Pharmacodynamics Furosemide manages hypertension and edema associated with congestive heart failure, cirrhosis, and renal disease, including the nephrotic syndrome.
Furosemide is a potent loop diuretic that works to increase the excretion of Na+ and water by the kidneys by inhibiting their reabsorption from the proximal and distal tubules, as well as the loop of Henle.9 It works directly acts on the cells of the nephron and indirectly modifies the content of the renal filtrate.8 Ultimately, furosemide increases the urine output by the kidney.

Protein-bound furosemide is delivered to its site of action in the kidneys and secreted via active secretion by nonspecific organic transporters expressed at the luminal site of action.4, 9 Following oral administration, the onset of the diuretic effect is about 1 and 1.5 hours 9, and the peak effect is reached within the first 2 hours.10 The duration of effect following oral administration is about 4-6 hours but may last up to 8 hours.12 Following intravenous administration, the onset of effect is within 5 minutes, and the peak effect is reached within 30 minutes.

The duration of action following intravenous administration is approximately 2 hours. Following intramuscular administration, the onset of action is somewhat delayed.9 Mechanism of action Furosemide promotes diuresis by blocking tubular reabsorption of sodium and chloride in the proximal and distal tubules, as well as in the thick ascending loop of Henle.

This diuretic effect is achieved through the competitive inhibition of sodium-potassium-chloride cotransporters (NKCC2) expressed along these tubules in the nephron, preventing the transport of sodium ions from the lumenal side into the basolateral side for reabsorption.

This inhibition results in increased excretion of water along with sodium, chloride, magnesium, calcium, hydrogen, and potassium ions.10 As with other loop diuretics, furosemide decreases the excretion of uric acid.8 Furosemide exerts direct vasodilatory effects, which results in its therapeutic effectiveness in the treatment of acute pulmonary edema.

Vasodilation leads to reduced responsiveness to vasoconstrictors, such as angiotensin II and noradrenaline, and decreased production of endogenous natriuretic hormones with vasoconstricting properties. It also leads to increased production of prostaglandins with vasodilating properties.


Target	Actions	Organism
A Solute carrier family 12 member 1	inhibitor	Humans
N Carbonic anhydrase 2	inhibitor	Humans
U G-protein coupled receptor 35	agonist	Humans

Absorption Following oral administration, furosemide is absorbed from the gastrointestinal tract.12 It displays variable bioavailability from oral dosage forms, ranging from 10 to 90%.4 The oral bioavailability of furosemide from oral tablets or oral solution is about 64% and 60%, respectively, of that from an intravenous injection of the drug.9 Volume of distribution The volume of distribution following intravenous administration of 40 mg furosemide were 0.181 L/kg in healthy subjects and 0.140 L/kg in patients with heart failure.6 Protein binding Plasma concentrations ranging from 1 to 400 mcg/mL are about 91-99% bound in healthy individuals.

The unbound fraction is about 2.3-4.1% at therapeutic concentrations.12 Furosemide mainly binds to serum albumin.9 Metabolism The metabolism of furosemide occurs mainly in the kidneys and the liver, to a smaller extent.
The kidneys are responsible for about 85% of total furosemide total clearance, where about 40% involves biotransformation.5 Two major metabolites of furosemide are furosemide glucuronide, which is pharmacologically active, and saluamine (CSA) or 4-chloro-5-sulfamoylanthranilic acid.2 Hover over products below to view reaction partners Route of elimination The kidneys are responsible for 85% of total furosemide total clearance, where about 43% of the drug undergoes renal excretion.5 Significantly more furosemide is excreted in urine following the I.V.

injection than after the tablet or oral solution. Approximately 50% of the furosemide load is excreted unchanged in urine, and the rest is metabolized into glucuronide in the kidney.4 Half-life The half-life from the dose of 40 mg furosemide was 4 hours following oral administration and 4.5 hours following intravenous administration. Improve decision support & research outcomes With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. Improve decision support & research outcomes with our structured adverse effects data.

Toxicity Clinical consequences from overdose depend on the extent of electrolyte and fluid loss and include dehydration, blood volume reduction, hypotension, electrolyte imbalance, hypokalemia, hypochloremic alkalosis, 9 hemoconcentration, cardiac arrhythmias (including A-V block and ventricular fibrillation).12 Symptoms of overdose include acute renal failure, thrombosis, delirious states, flaccid paralysis, apathy and confusion.

In cirrhotic patients, overdosage might precipitate hepatic coma.12 In rats, the oral LD 50, intraperitoneal LD 50, and subcutaneous LD 50 is 2600 mg/kg, 800 mg/kg, and 4600 mg/kg, respectively. The Lowest published toxic dose (TDLo) in a female is 6250 μg/kg.11 Pathways


Pathway	Category
Furosemide Action Pathway	Drug action

Pharmacogenomic Effects/ADRs Not Available Drug Interactions This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Approved
Vet approved
Nutraceutical
Illicit
Withdrawn
Investigational
Experimental
All Drugs


Drug	Interaction
Integrate drug-drug interactions in your software
Abacavir	Furosemide may increase the excretion rate of Abacavir which could result in a lower serum level and potentially a reduction in efficacy.
Abaloparatide	The risk or severity of adverse effects can be increased when Furosemide is combined with Abaloparatide.
Acamprosate	The excretion of Acamprosate can be decreased when combined with Furosemide.
Acarbose	The therapeutic efficacy of Acarbose can be decreased when used in combination with Furosemide.
Acebutolol	Furosemide may increase the hypotensive activities of Acebutolol.
Aceclofenac	The therapeutic efficacy of Furosemide can be decreased when used in combination with Aceclofenac.
Acemetacin	Furosemide may increase the nephrotoxic activities of Acemetacin.
Acetaminophen	Furosemide may increase the excretion rate of Acetaminophen which could result in a lower serum level and potentially a reduction in efficacy.
Acetazolamide	Acetazolamide may increase the excretion rate of Furosemide which could result in a lower serum level and potentially a reduction in efficacy.
Acetohexamide	The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Furosemide.

Food Interactions

Avoid excessive or chronic alcohol consumption. Alcohol increases the risk of orthostatic hypotension.
Avoid natural licorice. Avoid licorice in large amounts, as it may lead to hypokalemia.
Increase consumption of potassium-rich foods. This medication may cause potassium depletion. Foods containing potassium include bananas and orange juice.

Drug product information from 10+ global regions Our datasets provide approved product information including: dosage, form, labeller, route of administration, and marketing period. Access drug product information from over 10 global regions. Product Ingredients


Ingredient	UNII	CAS	InChI Key
Furosemide sodium	101EM454S7	41733-55-5	DLFCAVBMDSKMEY-UHFFFAOYSA-M

Product Images International/Other Brands Diurapid (Mibe Jena) / Diurin (Mylan) / Diurmessel (Biomep) / Eutensin (Sanofi) / Frumex / Frusenex / Frusol (Rosemont) / Furo-Puren (Actavis) / Seguril (Sanofi) Brand Name Prescription Products


Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
Fuosemide	Tablet	40 mg/1	Oral	NCS HealthCare of KY, Inc dba Vangard Labs	1983-11-10	2022-10-31
Furoscix	Injection	8 mg/1mL	Subcutaneous	scPharmaceuticals Inc.	2022-11-14	Not applicable
Furosemide	Injection, solution	10 mg/1mL	Intramuscular; Intravenous	Hospira, Inc.	2006-07-31	2006-07-31
Furosemide	Tablet	20 mg/1	Oral	Aphena Pharma Solutions – Tennessee, LLC	1981-08-27	Not applicable
Furosemide	Tablet	20 mg/1	Oral	Golden State Medical Supply, Inc.	1983-11-10	Not applicable
Furosemide	Tablet	20 mg/1	Oral	McKesson Contract Packaging	1983-11-30	2017-09-30
Furosemide	Tablet	40 mg/1	Oral	Safecor Health, LLC	2014-09-30	2019-11-11
Furosemide	Tablet	40 mg/1	Oral	Remedy Repack	2011-10-10	2012-10-10
Furosemide	Tablet	20 mg/1	Oral	Remedy Repack	2013-02-19	2014-03-20
Furosemide	Tablet	20 mg/1	Oral	Ncs Health Care Of Ky, Inc Dba Vangard Labs	1983-11-30	Not applicable

Generic Prescription Products


Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
Apo-furosemide	Tablet	40 mg	Oral	Apotex Corporation	1976-12-31	Not applicable
Apo-furosemide	Tablet	80 mg	Oral	Apotex Corporation	1986-12-31	Not applicable
Apo-furosemide	Tablet	20 mg	Oral	Apotex Corporation	1977-12-31	Not applicable
Ava-furosemide	Tablet	80 mg	Oral	Avanstra Inc	2011-08-11	2014-08-21
Ava-furosemide	Tablet	40 mg	Oral	Avanstra Inc	2011-08-11	2014-08-21
Ava-furosemide	Tablet	20 mg	Oral	Avanstra Inc	2011-08-11	2014-08-21
Bio-furosemide	Tablet	20 mg	Oral	Biomed Pharma	2003-04-11	2022-07-19
Bio-furosemide	Tablet	40 mg	Oral	Biomed Pharma	2003-04-11	2022-07-19
Dom-furosemide	Tablet	40 mg	Oral	Biomed Pharma	2003-10-14	2013-08-02
Dom-furosemide	Tablet	20 mg	Oral	Biomed Pharma	2003-10-14	2013-08-02

Mixture Products


Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
14-Panel Toxicology Medicated Collection System	Furosemide (20 mg/1) + Benzalkonium chloride (0.13 g/100g)	Kit; Liquid; Tablet	Oral; Topical	Morkin Companies, Inc DBA Medical Technologies, Inc	2022-01-26	Not applicable
Active-Medicated specimen collection kit	Furosemide (20 mg/1) + Benzalkonium chloride (0.0013 g/1mL)	Kit	Oral; Topical	N.O.R.T.H., Inc.	2013-10-31	Not applicable
Diascreen 12-Panel Medicated Collection System	Furosemide (20 mg/1) + Benzalkonium chloride (0.13 g/100g)	Kit	Oral; Topical	It3 Medical Llc	2016-07-27	Not applicable
Diuscreen Medicated Collection Kit	Furosemide (20 mg/1) + Benzalkonium chloride (0.0013 g/1mL)	Kit	Oral; Topical	Maveron Health, LLC.	2015-06-01	2016-10-28
Diuscreen Multi-Drug Medicated Test Kit	Furosemide (20 mg/1) + Benzalkonium chloride (0.0013 g/1mL)	Kit	Oral; Topical	Maveron Health, LLC.	2015-06-01	2016-10-28
Furo-Spirobene – Filmtabletten	Furosemide (20 mg) + Spironolactone (50 mg)	Tablet, film coated	Oral	Teva B.V.	1997-04-07	Not applicable
Furo-Spirobene forte – Filmtabletten	Furosemide (20 mg) + Spironolactone (100 mg)	Tablet, film coated	Oral	Teva B.V.	1997-04-07	Not applicable
Lasilacton 20 mg/100 mg Kapseln	Furosemide (20 mg) + Spironolactone (100 mg)	Capsule	Oral	Sanofi Aventis Gmb H	1981-12-07	Not applicable
Lasilacton 20 mg/50 mg Kapseln	Furosemide (20 mg) + Spironolactone (50 mg)	Capsule	Oral	Sanofi Aventis Gmb H	1981-12-07	Not applicable
OSYROL 100 LASIX	Furosemide (20 mg) + Spironolactone (100 mg)	Capsule	Oral		2012-04-01	Not applicable

Unapproved/Other Products


Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
Furosemide	Furosemide (20 mg/1)	Tablet	Oral	Remedy Repack	2010-11-01	2011-02-10
Specimen Collection Kit	Furosemide (20 mg/1) + Benzalkonium chloride (0.13 mg/1mL)	Kit	Oral	Alvix Laboratories, LLC	2015-04-21	2019-01-28

UNII 7LXU5N7ZO5 CAS number 54-31-9 InChI Key ZZUFCTLCJUWOSV-UHFFFAOYSA-N InChI InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19) IUPAC Name 4-chloro-2- -5-sulfamoylbenzoic acid SMILES NS(=O)(=O)C1=C(Cl)C=C(NCC2=CC=CO2)C(=C1)C(O)=O Synthesis Reference Angelo Signor, Alfredo Guerrato, Giovanni Signor, “Process for the preparation of furosemide.” U.S.

Prandota J: Clinical pharmacology of furosemide in children: a supplement. Am J Ther.2001 Jul-Aug;8(4):275-89.
Ponto LL, Schoenwald RD: Furosemide (frusemide). A pharmacokinetic/pharmacodynamic review (Part I). Clin Pharmacokinet.1990 May;18(5):381-408. doi: 10.2165/00003088-199018050-00004.
Prandota J: Furosemide: progress in understanding its diuretic, anti-inflammatory, and bronchodilating mechanism of action, and use in the treatment of respiratory tract diseases. Am J Ther.2002 Jul-Aug;9(4):317-28.
Oh SW, Han SY: Loop Diuretics in Clinical Practice. Electrolyte Blood Press.2015 Jun;13(1):17-21. doi: 10.5049/EBP.2015.13.1.17. Epub 2015 Jun 30.
Pichette V, du Souich P: Role of the kidneys in the metabolism of furosemide: its inhibition by probenecid. J Am Soc Nephrol.1996 Feb;7(2):345-9.
Andreasen F, Mikkelsen E: Distribution, elimination and effect of furosemide in normal subjects and in patients with heart failure. Eur J Clin Pharmacol.1977 Aug 17;12(1):15-22. doi: 10.1007/bf00561400.
Perez J, Sitar DS, Ogilvie RI: Biotransformation of furosemide in patients with acute pulmonary edema. Drug Metab Dispos.1979 Nov-Dec;7(6):383-7.
28. (2012). In Rang and Dale’s Pharmacology (7th ed., pp.352-354). Edinburgh: Elsevier/Churchill Livingstone.
FDA Approved Drug Products: Furosemide Injection, for intravenous or intramuscular use
Furosemide – StatPearls – NCBI Bookshelf
Furosemide SAFETY DATA SHEET – Cayman Chemical
Lasix Oral (furosemide) Product Monograph
FDA Approved Drug Products: Furoscix (furosemide injection), for subcutaneous use (October 2022)

External Links Human Metabolome Database HMDB0001933 KEGG Drug D00331 KEGG Compound C07017 PubChem Compound 3440 PubChem Substance 46506779 ChemSpider 3322 BindingDB 25902 RxNav 4603 ChEBI 47426 ChEMBL CHEMBL35 ZINC ZINC000000035804 Therapeutic Targets Database DAP000043 PharmGKB PA449719 PDBe Ligand FUN RxList RxList Drug Page Drugs.com Drugs.com Drug Page Wikipedia Furosemide PDB Entries 1z9y / 2xn5 / 3rf4 / 6de9 / 6sg0 / 7n3n / 7sfl Manufacturers

Abraxis pharmaceutical products
App pharmaceuticals llc
Astrazeneca lp
Baxter healthcare corp anesthesia and critical care
Hospira inc
International medication system
Luitpold pharmaceuticals inc
Marsam pharmaceuticals llc
Organon usa inc
Smith and nephew solopak div smith and nephew
Warner chilcott div warner lambert co
Watson laboratories inc
Wockhardt ltd
Wyeth ayerst laboratories
Sanofi aventis us llc
Roxane laboratories inc
Wockhardt eu operations (swiss) ag
Dava pharmaceuticals inc
Excellium pharmaceutical inc
International medication systems ltd
Ipca laboratories ltd
Ivax pharmaceuticals inc sub teva pharmaceuticals usa
Kalapharm inc
Mutual pharmaceutical co inc
Mylan pharmaceuticals inc
Sandoz inc
Superpharm corp
Vintage pharmaceuticals inc
County line pharmaceuticals llc

Packagers

Advanced Pharmaceutical Services Inc.
American Regent
Amerisource Health Services Corp.
Apotheca Inc.
APP Pharmaceuticals
A-S Medication Solutions LLC
Bryant Ranch Prepack
C.O. Truxton Inc.
Cardinal Health
Central Texas Community Health Centers
Comprehensive Consultant Services Inc.
Coupler Enterprises Inc.
CVS Pharmacy
DAVA Pharmaceuticals
Dept Health Central Pharmacy
DHHS Program Support Center Supply Service Center
Direct Dispensing Inc.
Dispensing Solutions
Diversified Healthcare Services Inc.
Excellium Pharmaceutical Inc.
General Injectables and Vaccines Inc.
Goldline Laboratories Inc.
Group Health Cooperative
H and H Laboratories
Heartland Repack Services LLC
Hospira Inc.
Intervet International
Ipca Laboratories Ltd.
Ivax Pharmaceuticals
Kaiser Foundation Hospital
Lake Erie Medical and Surgical Supply
Liberty Pharmaceuticals
Luitpold Pharmaceuticals Inc.
Macnary Ltd.
Major Pharmaceuticals
Mason Distributors
Mckesson Corp.
Medvantx Inc.
Merrell Pharmaceuticals Inc.
Murfreesboro Pharmaceutical Nursing Supply
Mylan
Neighborcare Repackaging Inc.
Neuman Distributors Inc.
Norwich Pharmaceuticals Inc.
Nucare Pharmaceuticals Inc.
Ohm Laboratories Inc.
Palmetto Pharmaceuticals Inc.
Patheon Inc.
PCA LLC
PD-Rx Pharmaceuticals Inc.
Pharmaceutical Utilization Management Program VA Inc.
Pharmedix
Physicians Total Care Inc.
Preferred Pharmaceuticals Inc.
Prepackage Specialists
Prepak Systems Inc.
Qualitest
Ranbaxy Laboratories
Rebel Distributors Corp.
Redpharm Drug
Remedy Repack
Roxane Labs
Sandhills Packaging Inc.
Sandoz
Sanofi-Aventis Inc.
Southwood Pharmaceuticals
Spectrum Pharmaceuticals
Stat Scripts LLC
Talbert Medical Management Corp.
Taylor Pharmaceuticals
Tya Pharmaceuticals
UDL Laboratories
United Research Laboratories Inc.
Va Cmop Dallas
Vangard Labs Inc.
Vatring Pharmaceuticals
Vedco Inc.
Vintage Pharmaceuticals Inc.
Watson Pharmaceuticals
Wockhardt Ltd.

Dosage Forms


Form	Route	Strength
Kit	Oral; Topical
Tablet	Oral	20 mg
Tablet	Oral	40 mg
Solution		10 mg/1ml
Tablet	Oral
Tablet	Oral
Tablet	Oral	40.00 mg
Tablet	Oral	250 MG
Injection, solution	Intravenous	20 mg/2ml
Injection, solution, concentrate	Parenteral	250 mg
Injection, solution	Intravenous	40 mg/4ml
Capsule, extended release	Oral	120 MG
Tablet	Oral	125 MG
Capsule, extended release	Oral	30 MG
Injection, solution	Parenteral	40 MG/4ML
Capsule, extended release	Oral	60 MG
Injection	Subcutaneous	8 mg/1mL
Solution	Parenteral	10 MG/ML
Injection, solution	Parenteral	10 mg/ml
Solution	Parenteral	250 MG/25ML
Solution	Parenteral	20 mg
Tablet, film coated	Oral	40 mg
Capsule, coated	Oral
Injection	Intramuscular; Intravascular	10 mg/1mL
Injection	Intramuscular; Intravenous	10 mg/2mL
Injection	Intramuscular; Intravenous	10 mg/1mL
Injection	Intramuscular; Intravenous	100 mg/10mL
Injection	Intramuscular; Intravenous	20 mg/2mL
Injection	Intramuscular; Intravenous	40 mg/4mL
Injection	Intravenous	10 mg/1mL
Injection, solution	Intramuscular; Intravenous
Injection, solution	Intramuscular; Intravenous	10 mg/1mL
Injection, solution	Intramuscular; Intravenous	100 mg/10mL
Injection, solution	Intramuscular; Intravenous	20 mg/2mL
Injection, solution	Intramuscular; Intravenous	40 mg/4mL
Injection, solution	Intravenous	10 mg/1mL
Solution	Oral	10 mg/1mL
Solution	Oral	40 mg/4mL
Solution	Oral	40 mg/5mL
Tablet	Oral	20 mg/1
Tablet	Oral	40 mg/1
Tablet	Oral	80 mg/1
Tablet, film coated	Oral
Injection, solution		10 MG/ML
Injection, solution
Liquid	Intramuscular; Intravenous	10 mg / mL
Solution	Intramuscular; Intravenous	10 mg / mL
Solution	Intramuscular; Intravenous	20 mg / 2 mL
Injection, solution		20 MG/2ML
Tablet	Oral	25 MG
Solution	Intravenous	250 mg / 25 mL
Liquid	Intravenous	250 mg / 25 mL
Solution	Intravenous	10 mg / mL
Injection, solution	Intramuscular; Intravenous	50 mg/5mL
Injection	Intramuscular; Intravenous	10 mg/ml
Injection	Intramuscular; Intravenous
Drug delivery system	Topical	20 mg
Capsule, gelatin coated	Oral
Capsule	Oral
Injection, solution		250 MG/25ML
Solution	Oral	10 MG/ML
Injection, solution, concentrate	Intravenous	250 mg/25mL
Solution	Parenteral	250 MG
Tablet	Oral	80 mg / tab
Solution	Intravenous	20 mg
Injection, solution	Parenteral	20 MG/2ML
Solution	Oral	10 mg / mL
Liquid	Oral	10 mg / mL
Liquid	Intramuscular; Intravenous	20 mg / 2 mL
Capsule	Oral	30 mg
Capsule	Oral	60 mg
Liquid	Intravenous	10 mg / mL
Injection		20 mg/2ml
Tablet	Oral	80 mg
Kit	Oral
Tablet, film coated	Oral
Injection, solution	Parenteral
Kit; liquid; tablet	Oral; Topical
Kit; swab; tablet	Oral; Topical
Injection
Solution	Intramuscular; Intravenous	20 mg/2ml
Kit	Not applicable; Oral; Topical
Solution	Intramuscular; Intravenous	20 mg
Solution	Oral
Tablet, coated	Oral	40 mg
Tablet	Oral	500 mg
Injection, solution		10 mg/1ml

Prices


Unit description	Cost	Unit
Hydro 40 40% Foam 150 gm Can	182.52USD	can
Hydro 40 40% Foam 70 gm Can	148.99USD	can
Furosemide 10 mg/ml Solution 60ml Bottle	17.99USD	bottle
Furosemide 10 mg/ml Solution 120ml Bottle	15.98USD	bottle
Furosemide powder	3.51USD	g
Lasix Special 500 mg Tablet	3.25USD	tablet
Urex 1 gm tablet	2.47USD	tablet
Furosemide 10 mg/ml cartrg	1.45USD	ml
Lasix 80 mg tablet	1.0USD	tablet
Furosemide 10 mg/ml Solution	0.9USD	ml
Furosemide 10 mg/ml	0.75USD	ml
Lasix 40 mg tablet	0.53USD	tablet
Furosemide 80 mg tablet	0.45USD	tablet
Lasix 20 mg tablet	0.42USD	tablet
Lasix 10 mg/ml Solution	0.3USD	ml
CVS Pharmacy diuretic 50 mg softgel	0.17USD	softgel capsule
Furosemide 40 mg tablet	0.16USD	tablet
Furosemide 20 mg tablet	0.14USD	tablet
Apo-Furosemide 80 mg Tablet	0.13USD	tablet
Novo-Semide 80 mg Tablet	0.13USD	tablet
Nat herbal diuretic tablet sa	0.1USD	tablet
Apo-Furosemide 40 mg Tablet	0.07USD	tablet
Natural herbal diuretic tablet	0.07USD	tablet
Novo-Semide 40 mg Tablet	0.07USD	tablet
Apo-Furosemide 20 mg Tablet	0.05USD	tablet
Novo-Semide 20 mg Tablet	0.05USD	tablet

DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only. Patents


Patent Number	Pediatric Extension	Approved	Expires (estimated)	Region
US11433044	No	2014-04-03	2034-04-03
US9884039	No	2018-02-06	2034-04-03
US10272064	No	2019-04-30	2034-04-03

State Solid Experimental Properties


Property	Value	Source
melting point (°C)	220	MSDS
water solubility	73.1 mg/L (at 30 °C)	YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP	2.03	SANGSTER (1993)
logS	-3.66	ADME Research, USCD
Caco2 permeability	-6.5	ADME Research, USCD

Predicted Properties


Property	Value	Source
Water Solubility	0.118 mg/mL	ALOGPS
logP	2.71	ALOGPS
logP	1.75	Chemaxon
logS	-3.4	ALOGPS
pKa (Strongest Acidic)	4.25	Chemaxon
pKa (Strongest Basic)	-1.5	Chemaxon
Physiological Charge	-1	Chemaxon
Hydrogen Acceptor Count	5	Chemaxon
Hydrogen Donor Count	3	Chemaxon
Polar Surface Area	122.63 Å 2	Chemaxon
Rotatable Bond Count	5	Chemaxon
Refractivity	77.47 m 3 ·mol -1	Chemaxon
Polarizability	30.55 Å 3	Chemaxon
Number of Rings	2	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	Yes	Chemaxon
Veber’s Rule	No	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features


Property	Value	Probability
Human Intestinal Absorption	+	0.9155
Blood Brain Barrier	–	0.8833
Caco-2 permeable	–	0.6436
P-glycoprotein substrate	Non-substrate	0.8775
P-glycoprotein inhibitor I	Non-inhibitor	0.9272
P-glycoprotein inhibitor II	Non-inhibitor	0.8382
Renal organic cation transporter	Non-inhibitor	0.924
CYP450 2C9 substrate	Non-substrate	0.6878
CYP450 2D6 substrate	Non-substrate	0.8351
CYP450 3A4 substrate	Non-substrate	0.6789
CYP450 1A2 substrate	Non-inhibitor	0.9045
CYP450 2C9 inhibitor	Non-inhibitor	0.907
CYP450 2D6 inhibitor	Non-inhibitor	0.9231
CYP450 2C19 inhibitor	Non-inhibitor	0.9025
CYP450 3A4 inhibitor	Non-inhibitor	0.9602
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.6885
Ames test	Non AMES toxic	0.9132
Carcinogenicity	Non-carcinogens	0.6469
Biodegradation	Not ready biodegradable	0.9881
Rat acute toxicity	2.1362 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.9342
hERG inhibition (predictor II)	Non-inhibitor	0.8525

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. ( 23092397 )

Does milk have a diuretic effect?

Milk is a substance that promotes the production of urine, which is the reason it is considered a diuretic.

What should you avoid when taking diuretics?

Aldactone ( spironolactone ) Bumex ( bumetanide ) Demadex ( torsemide ) Esidrix ( hydrochlorothiazide )Lasix ( furosemide ) Zaroxolyn ( metolazone )

Diuretics come in different categories:

Different diuretics can be taken together, and you can take them with other medications, sometimes in the same pill. Your doctor may recommend a diuretic if you have:

The number of doses you take each day, the time allowed between doses, and how long you need to take a diuretic will depend on the type prescribed, as well as your condition.
Weigh yourself at the same time every day (on the same scale) and write down your weight,
Call your doctor if you gain 3 pounds in one day or 5 pounds in one week.

Herbal preparationsOver-the-counter drugs VitaminsNutrition supplements

Medication for high blood pressure DigoxinIndomethacin Probenecid Corticosteroids

Some diuretics may require you to avoid or eat certain foods. Follow your doctor’s advice, which may include:

A low-salt diet A potassium supplement or high-potassium foods such as bananas and orange juice.

They’ll probably tell you to follow a low-sodium diet and limit how much salt you eat. Because some diuretics also pull potassium out of your body, you might need to eat more foods like bananas, sweet potatoes, spinach, and lentils, or take a potassium supplement. On the other hand, if you’re taking a potassium-sparing diuretic, such as amiloride (Midamar), spironolactone (Aldactone), or triamterene (Dyrenium), they may want you to avoid potassium-rich foods, salt substitutes, low-sodium milk, and other sources of potassium.

If you’re taking two doses each day, take the second dose no later than late afternoon so you can sleep through the night without waking up to urinate.
You also run the risk of getting dehydrated, and simply drinking more fluids may not be enough.
Call your doctor if you’re very thirsty or have a very dry mouth, your pee is a deep yellow, you aren’t peeing much or get constipated, or you have a bad headache,

Your blood chemistry can get thrown off.
You could have too little or too much sodium or potassium in your system.
This can make you tired or weak or give you muscle cramps or a headache,
It’s rare, but your heart may speed up (over 100 beats a minute) or you might start throwing up because of a dangerously low potassium level.

Fever, sore throat, cough, ringing in the ears, unusual bleeding or bruising, rapid and excessive weight loss Skin rash Loss of appetite, nausea, vomiting, or muscle cramps

Is milk a good diuretic?

Yes, Milk Is Hydrating, According to Research – The rumors are true: Milk is a great source of hydration. A March 2016 trial in The American Journal of Clinical Nutrition compared the effects of a variety of drinks—skim milk, whole milk, cola, diet cola, hot tea, iced tea, coffee, lager, orange juice, sparkling water, and a sports drink—on participants’ fluid balances and then compared the results to still water.

The findings indicated that both skim milk and whole milk are more hydrating than plain water, since when the participants drank milk they were able to retain fluids for longer periods of time than when they drank water.
Later studies have found comparable results.
For instance, a May 2020 study in Nutrients found milk-containing beverages superior to water in their abilities to sustain fluids after ingestion.

In fact, milk was found to have significantly higher effects on bodily hydration than water. In both studies, researchers found that milk is associated with a lower urine output (peeing less frequently and therefore experiencing less fluid loss) compared to water.

There’s nothing wrong with peeing—and you should be visiting the restroom several times throughout the day to do so; however, emptying your bladder immediately after ingesting liquids isn’t always best.
Drinking milk and not having to go immediately after is an indicator that its hydrating effects last longer.

“Milk is about 90 percent water, meaning it can be a good source of hydration, especially in the summer months where people are more at risk for dehydration,” confirms clinical dietitian Patricia Kolesa, R.D. “It also contains sodium and potassium, the electrolytes needed to replace what we sweat.”

Why do you take furosemide on an empty stomach?

Taking the Medicine – Furosemide is absorbed most completely when it is taken on an empty stomach. This medication may cause stomach upset, however, which tends to be less of a problem when it is taken with food or milk. As the dose should be adjusted individually, with the help of blood tests, let your doctor know if you will change the way you take this drug.